Pub. Date : 2009 Oct 1
PMID : 19622383
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Coordinated regulation of angiopoietin-1 and vascular endothelial growth factor by arsenite in human brain microvascular pericytes: implications of arsenite-induced vascular dysfunction. | arsenite | vascular endothelial growth factor A | Homo sapiens |
| 2 | In this study, we used human brain microvascular pericytes (HBMP) to evaluate the effects of arsenite on Ang-1 and VEGF regulation. | arsenite | vascular endothelial growth factor A | Homo sapiens |
| 3 | Arsenite decreased Ang-1 secretion in a time and dose-dependent manner, while it increased VEGF secretion. | arsenite | vascular endothelial growth factor A | Homo sapiens |
| 4 | Contrary to Ang-1, the expression of VEGF mRNA was dose-dependently up-regulated by arsenite. | arsenite | vascular endothelial growth factor A | Homo sapiens |
| 5 | Treatment with N-actyl-l:-cysteine (NAC) alone decreased the release of Ang-1, but failed to attenuate the arsenite-induced decrease in Ang-1 secretion, while NAC completely blocked the arsenite-stimulated VEGF secretion. | arsenite | vascular endothelial growth factor A | Homo sapiens |
| 6 | These results indicate that reactive oxygen species are involved in the regulation of VEGF, but not of Ang-1, secretion in response to arsenite treatment in pericytes. | arsenite | vascular endothelial growth factor A | Homo sapiens |
| 7 | In conclusion, arsenite decreases Ang-1 secretion and increases VEGF secretion, which may offer new insight into understanding the arsenite toxicity associated with vascular instability and subsequent development of vascular disease. | arsenite | vascular endothelial growth factor A | Homo sapiens |