Pub. Date : 2009 Dec
PMID : 19622377
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We expressed the gamma-aminobutyric acid (GABA) transporter GAT1 (SLC6A1) in Xenopus laevis oocytes and performed GABA uptake experiments under voltage clamp at different membrane potentials as well as in the presence of the specific GAT1 inhibitors SKF-89976A and NO-711. | gamma-Aminobutyric Acid | solute carrier family 6 (neurotransmitter transporter), member 1 S homeolog | Xenopus laevis |
| 2 | We expressed the gamma-aminobutyric acid (GABA) transporter GAT1 (SLC6A1) in Xenopus laevis oocytes and performed GABA uptake experiments under voltage clamp at different membrane potentials as well as in the presence of the specific GAT1 inhibitors SKF-89976A and NO-711. | gamma-Aminobutyric Acid | solute carrier family 6 (neurotransmitter transporter), member 1 S homeolog | Xenopus laevis |
| 3 | We expressed the gamma-aminobutyric acid (GABA) transporter GAT1 (SLC6A1) in Xenopus laevis oocytes and performed GABA uptake experiments under voltage clamp at different membrane potentials as well as in the presence of the specific GAT1 inhibitors SKF-89976A and NO-711. | gamma-Aminobutyric Acid | solute carrier family 6 (neurotransmitter transporter), member 1 S homeolog | Xenopus laevis |
| 4 | We expressed the gamma-aminobutyric acid (GABA) transporter GAT1 (SLC6A1) in Xenopus laevis oocytes and performed GABA uptake experiments under voltage clamp at different membrane potentials as well as in the presence of the specific GAT1 inhibitors SKF-89976A and NO-711. | gamma-Aminobutyric Acid | solute carrier family 6 (neurotransmitter transporter), member 1 S homeolog | Xenopus laevis |
| 5 | In the absence of the inhibitors, GAT1 mediated the inward translocation of 2 net positive charges across the plasma membrane for every GABA molecule transported into the cell. | gamma-Aminobutyric Acid | solute carrier family 6 (neurotransmitter transporter), member 1 S homeolog | Xenopus laevis |
| 6 | The results are not consistent with previous hypotheses that (i) GABA evokes an uncoupled channel-mediated current in GAT1, and (ii) GAT1 inhibitors block the putative uncoupled current gated by GABA. | gamma-Aminobutyric Acid | solute carrier family 6 (neurotransmitter transporter), member 1 S homeolog | Xenopus laevis |
| 7 | The results are not consistent with previous hypotheses that (i) GABA evokes an uncoupled channel-mediated current in GAT1, and (ii) GAT1 inhibitors block the putative uncoupled current gated by GABA. | gamma-Aminobutyric Acid | solute carrier family 6 (neurotransmitter transporter), member 1 S homeolog | Xenopus laevis |
| 8 | Rather, the results suggest tight coupling of GAT1-mediated charge flux and GABA flux. | gamma-Aminobutyric Acid | solute carrier family 6 (neurotransmitter transporter), member 1 S homeolog | Xenopus laevis |