Title : Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation.

Pub. Date : 2009 Oct 15

PMID : 19617897






1 Functional Relationships(s)
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1 Here we show that epithelial cell transforming sequence 2 (Ect2), a guanine nucleotide exchange factor for Rho family GTPases, is coordinately amplified and overexpressed with PKCiota in NSCLC tumors. Guanine Nucleotides protein kinase C iota Homo sapiens