Pub. Date : 2009 Oct
PMID : 19608606
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Presence of the Fps1p aquaglyceroporin channel is essential for Hog1p activation, but suppresses Slt2(Mpk1)p activation, with acetic acid stress of yeast. | Acetic Acid | Fps1p | Saccharomyces cerevisiae S288C |
| 2 | When grown at pH 4.5, Saccharomyces cerevisiae acquires a resistance to inhibitory acetic acid levels ( approximately 0.1 M) by destabilizing Fps1p, the plasma membrane aquaglyceroporin that provides the main route for passive diffusional entry of this acid into the cell. | Acetic Acid | Fps1p | Saccharomyces cerevisiae S288C |
| 3 | Acetic acid stress transiently activates Hog1p mitogen-activated protein (MAP) kinase, which, in turn, phosphorylates Fps1p in order to target this channel for endocytosis and degradation in the vacuole. | Acetic Acid | Fps1p | Saccharomyces cerevisiae S288C |
| 4 | Lack of Fps1p therefore exerts opposing effects on the activation of Hog1p and Slt2p in yeast exposed to acetic acid stress. | Acetic Acid | Fps1p | Saccharomyces cerevisiae S288C |