Title : NMR structure and dynamics of the engineered fluorescein-binding lipocalin FluA reveal rigidification of beta-barrel and variable loops upon enthalpy-driven ligand binding.

Pub. Date : 2009 Aug 11

PMID : 19603796






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 As expected, FluA exhibits the lipocalin fold of BBP, comprising eight antiparallel beta-strands forming a beta-barrel with an alpha-helix attached to its side. flua transmembrane protein 158 Homo sapiens
2 Comparison of the NMR structure of free FluA with the X-ray structures of BBP.biliverdin IX(gamma) and FluA.fluorescein complexes revealed significant conformational changes in the binding pocket, which is formed by four loops at the open end of the beta-barrel as well as adjoining beta-strand segments. flua transmembrane protein 158 Homo sapiens