Title : A mechanism for incorporation of galectin-3 into the spliceosome through its association with U1 snRNP.

Pub. Date : 2009 Aug 18

PMID : 19603745






2 Functional Relationships(s)
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1 When nuclear extract was fractionated on glycerol gradients, some galectin-3 molecules cosedimented with snRNP complexes. Glycerol LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated Homo sapiens
2 This cosedimentation represents bona fide galectin-3--snRNP complexes as (i) immunoprecipitation of gradient fractions with anti-galectin-3 yielded several complexes with varying ratios of snRNAs and associated proteins and (ii) the distribution of galectin-3--snRNP complexes was altered when the glycerol gradient was sedimented in the presence of lactose, a galectin ligand. Glycerol LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated Homo sapiens