Title : 3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma.

Pub. Date : 2009 Aug 1

PMID : 19602588






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 PIP(3) recruits PDK1 and AKT to the cell membrane through interactions with their pleckstrin homology domains, allowing PDK1 to activate AKT by phosphorylating it at residue threonine-308. pip(3) AKT serine/threonine kinase 1 Homo sapiens
2 PIP(3) recruits PDK1 and AKT to the cell membrane through interactions with their pleckstrin homology domains, allowing PDK1 to activate AKT by phosphorylating it at residue threonine-308. pip(3) AKT serine/threonine kinase 1 Homo sapiens