Pub. Date : 2009 Sep
PMID : 19592534
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Overexpression of the hydroxymethylglutaryl-coenzyme A reductase (HMG1) gene, which encodes the major rate-limiting enzyme of the mevalonate pathway, resulted in overproduction of squalene (191.9 mg liter(-1)) rather than GGOH (0.2 mg liter(-1)) in test tube cultures. | Squalene | hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 | Saccharomyces cerevisiae S288C |
| 2 | Coexpression of the BTS1-DPP1 fusion gene along with the HMG1 gene partially redirected the metabolic flux from squalene to GGOH. | Squalene | hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 | Saccharomyces cerevisiae S288C |