Title : Dicoumarol enhances doxorubicin-induced cytotoxicity in p53 wild-type urothelial cancer cells through p38 activation.

Pub. Date : 2010 Feb

PMID : 19583730






2 Functional Relationships(s)
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1 The combined treatment with dicoumarol suppressed p53/p21 induction by doxorubicin and resulted in sequential p38 MAPK activation, myeloid cell leukaemia 1 suppression and caspase cleavage. Dicumarol H3 histone pseudogene 16 Homo sapiens
2 CONCLUSION: These results suggest that concomitant use of dicoumarol could enhance the cytotoxicity of doxorubicin in urothelial cancer cells with wt-p53 through the p53/p21/p38 MAPK pathways. Dicumarol H3 histone pseudogene 16 Homo sapiens