Title : On the inhibition of glutamic acid decarboxylase and gamma-aminobutyric acid transaminase by sodium cyanide.

Pub. Date : 1991 Oct

PMID : 1956876






3 Functional Relationships(s)
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Protein Name
Organism
1 With no pyridoxal-5-phosphate added, GAD was non-competitively inhibited by NaCN, with an IC50 of 280 microM. Pyridoxal Phosphate glutamate decarboxylase 1 Homo sapiens
2 GAD was also inhibited when exposed to an equimolar amount of NaCN and pyridoxal-5-phosphate. Pyridoxal Phosphate glutamate decarboxylase 1 Homo sapiens
3 The gamma-aminobutyric acid synthesizing enzyme, GAD may thus be inhibited in vivo by NaCN or by a reaction product of NaCN and pyridoxal-5-phosphate. Pyridoxal Phosphate glutamate decarboxylase 1 Homo sapiens