Title : The interaction of mitochondrial iron with manganese superoxide dismutase.

Pub. Date : 2009 Aug 21

PMID : 19561359






3 Functional Relationships(s)
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1 Although mitochondrial iron does not normally bind SOD2, iron will misincorporate into Saccharomyces cerevisiae Sod2p when cells are starved for manganese or when mitochondrial iron homeostasis is disrupted by mutations in yeast grx5, ssq1, and mtm1. Iron Hsp70 family ATPase SSQ1 Saccharomyces cerevisiae S288C
2 Although mitochondrial iron does not normally bind SOD2, iron will misincorporate into Saccharomyces cerevisiae Sod2p when cells are starved for manganese or when mitochondrial iron homeostasis is disrupted by mutations in yeast grx5, ssq1, and mtm1. Iron Hsp70 family ATPase SSQ1 Saccharomyces cerevisiae S288C
3 Iron binds Sod2p in yeast mutants blocking late stages of iron-sulfur cluster biogenesis (grx5, ssq1, and atm1), but not in mutants defective in the upstream Isu proteins that serve as scaffolds for iron-sulfur biosynthesis. Iron Hsp70 family ATPase SSQ1 Saccharomyces cerevisiae S288C