Title : Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR.

Pub. Date : 2009 Aug 21

PMID : 19561084






1 Functional Relationships(s)
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1 However, under diabetic-mimicking conditions mTOR inhibits phosphatidylinositol (PI) 3-kinase/Akt signaling by phosphorylating insulin receptor substrate-1 (IRS-1) at Ser-636/639. Phosphatidylinositols insulin receptor substrate 1 Homo sapiens