Title : Rapid and efficient hydrophilicity tuning of p53/mdm2 antagonists.

Pub. Date : 2009 Jul-Aug

PMID : 19548636






1 Functional Relationships(s)
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1 We used the Orru three component reaction (O-3CR) along with a rapid and efficient, recently discovered amidation reaction to dramatically improve the water solubility of our recently discovered low molecular weight p53/mdm2 antagonists. Water tumor protein p53 Homo sapiens