Title : Cytokine-dependent regulation of NADPH oxidase activity and the consequences for activated T cell homeostasis.

Pub. Date : 2009 Jul 6

PMID : 19546249






2 Functional Relationships(s)
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1 Using mice deficient for the catalytic subunit gp91(phox) to characterize the molecular link to activated T cell apoptosis, we show that gp91(phox)-deficient T (T(-/-)) cells generated mitochondrial superoxide but had diminished hydrogen peroxide production in response to neglect, which, in turn, regulated Jun N-terminal kinase-dependent Bax activation and apoptosis. Superoxides paired Ig-like receptor B Mus musculus
2 Using mice deficient for the catalytic subunit gp91(phox) to characterize the molecular link to activated T cell apoptosis, we show that gp91(phox)-deficient T (T(-/-)) cells generated mitochondrial superoxide but had diminished hydrogen peroxide production in response to neglect, which, in turn, regulated Jun N-terminal kinase-dependent Bax activation and apoptosis. Superoxides paired Ig-like receptor B Mus musculus