Pub. Date : 2009 Sep
PMID : 19546240
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Up-regulation of UDP-glucuronosyltransferase (UGT) 1A4 by 17beta-estradiol: a potential mechanism of increased lamotrigine elimination in pregnancy. | Lamotrigine | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 2 | In this study, we show that 17beta-estradiol (E(2)) up-regulates expression of UDP glucuronosyltransferase (UGT) 1A4, the major enzyme responsible for elimination of lamotrigine. | Lamotrigine | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 3 | Together, our data indicate that up-regulation of UGT1A4 expression by E(2) is mediated by both ER alpha and Sp1 and is a potential mechanism contributing to the enhanced elimination of lamotrigine in pregnancy. | Lamotrigine | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |