Pub. Date : 2009 Jul 1
PMID : 19542465
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | LL-37 complexation with glycosaminoglycans in cystic fibrosis lungs inhibits antimicrobial activity, which can be restored by hypertonic saline. | Glycosaminoglycans | cathelicidin antimicrobial peptide | Homo sapiens |
| 2 | The endogenous LL-37 in CF BAL fluid is protected from this proteolysis by interactions with glycosaminoglycans, but while this protects LL-37 from proteolysis it results in inactivation of LL-37 antimicrobial activity. | Glycosaminoglycans | cathelicidin antimicrobial peptide | Homo sapiens |
| 3 | By digesting glycosaminoglycans in CF BAL fluid, endogenous LL-37 is liberated and the antimicrobial properties of CF BAL fluid restored. | Glycosaminoglycans | cathelicidin antimicrobial peptide | Homo sapiens |
| 4 | This is also seen in vivo in CF sputum where LL-37 is complexed to glycosaminoglycans but is liberated following nebulized hypertonic saline resulting in increased antimicrobial effect. | Glycosaminoglycans | cathelicidin antimicrobial peptide | Homo sapiens |