Pub. Date : 2009 Aug 17
PMID : 19540326
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tetramethylpyrazine suppresses interleukin-8 expression in LPS-stimulated human umbilical vein endothelial cell by blocking ERK, p38 and nulear factor-kappaB signaling pathways. | tetramethylpyrazine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | AIM OF THE STUDY: To determine the anti-inflammatory effects of Tetramethylpyrazine (TMP) and to investigate the inhibitory effect of TMP on IL-8 production in human umbilical vein endothelial cells (HUVECs) induced by LPS might be mediated by inhibiting p38, ERK and NF-kappaB signaling pathways. | tetramethylpyrazine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | RESULTS: TMP inhibits LPS-induced IL-8 production in HUVECs at both the protein and mRNA levels, suggesting that TMP has an antiinflammatory effect on endothelial cells. | tetramethylpyrazine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 4 | RESULTS: TMP inhibits LPS-induced IL-8 production in HUVECs at both the protein and mRNA levels, suggesting that TMP has an antiinflammatory effect on endothelial cells. | tetramethylpyrazine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 5 | CONCLUSIONS: The inhibitory effect of TMP on the LPS-induced IL-8 production is mediated by the NF-kappaB-dependent pathway, and TMP also separately affects the ERK and p38 MAPK pathway. | tetramethylpyrazine | C-X-C motif chemokine ligand 8 | Homo sapiens |