Title : Claudin-2-dependent changes in noncharged solute flux are mediated by the extracellular domains and require attachment to the PDZ-scaffold.

Pub. Date : 2009 May

PMID : 19538292






3 Functional Relationships(s)
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1 It is also known that inducible expression of claudin-2, but not claudin-4, will selectively increase the permeability for polyethylene glycol (PEG) molecules which are <0.4 A in radius, but it is not known whether permeability is controlled by the same regions of claudins which control charge selectivity. Polyethylene Glycols claudin 2 Canis lupus familiaris
2 It is also known that inducible expression of claudin-2, but not claudin-4, will selectively increase the permeability for polyethylene glycol (PEG) molecules which are <0.4 A in radius, but it is not known whether permeability is controlled by the same regions of claudins which control charge selectivity. Polyethylene Glycols claudin 2 Canis lupus familiaris
3 Using inducible expression of chimeras of claudin-2 and claudin-4 in monolayers of MDCK II cells we show that the extracellular loops alone are responsible for controlling the permeability for noncharged PEGs as well as for charge selectivity. Polyethylene Glycols claudin 2 Canis lupus familiaris