Title : Structure of HI-6*sarin-acetylcholinesterase determined by X-ray crystallography and molecular dynamics simulation: reactivator mechanism and design.

Pub. Date : 2009 Jun 18

PMID : 19536291






2 Functional Relationships(s)
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1 Organophosphonates such as isopropyl metylphosphonofluoridate (sarin) are extremely toxic as they phosphonylate the catalytic serine residue of acetylcholinesterase (AChE), an enzyme essential to humans and other species. Sarin acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Organophosphonates such as isopropyl metylphosphonofluoridate (sarin) are extremely toxic as they phosphonylate the catalytic serine residue of acetylcholinesterase (AChE), an enzyme essential to humans and other species. Sarin acetylcholinesterase (Cartwright blood group) Homo sapiens