Pub. Date : 2009 Jun
PMID : 19528456
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Impact of tumor cell VEGF expression on the in vivo efficacy of vandetanib (ZACTIMA; ZD6474). | vandetanib | vascular endothelial growth factor A | Mus musculus |
| 2 | In the current study, the impact of VEGF expression on the response of tumors to the VEGFR2 associated tyrosine kinase inhibitor vandetanib was evaluated. | vandetanib | vascular endothelial growth factor A | Mus musculus |
| 3 | An intradermal angiogenesis assay was used to demonstrate that a 4-day treatment with vandetanib (50 mg/kg/day) was able to significantly inhibit blood vessel growth induced by both parental and high VEGF-expressing tumor cell clones. | vandetanib | vascular endothelial growth factor A | Mus musculus |
| 4 | In the HT29 tumor model, treatment response to vandetanib (50 mg/kg/day, Monday-Friday for 2 weeks) was greatest in xenografts derived from the highest VEGF-expressing cell clones. | vandetanib | vascular endothelial growth factor A | Mus musculus |
| 5 | The present findings indicate that vandetanib therapy effectively counteracted the aggressive feature of tumor growth resulting from VEGF over-expressing tumor cells and suggest that such tumors may be particularly well suited for anti-VEGF interventions. | vandetanib | vascular endothelial growth factor A | Mus musculus |
| 6 | The present findings indicate that vandetanib therapy effectively counteracted the aggressive feature of tumor growth resulting from VEGF over-expressing tumor cells and suggest that such tumors may be particularly well suited for anti-VEGF interventions. | vandetanib | vascular endothelial growth factor A | Mus musculus |