Title : Methadone induces the expression of hepatic drug-metabolizing enzymes through the activation of pregnane X receptor and constitutive androstane receptor.

Pub. Date : 2009 Sep

PMID : 19520773






1 Functional Relationships(s)
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1 Real-time polymerase chain reaction analysis of human hepatocyte cultures revealed that MD induces the mRNA expression of CYP2B6, CYP3A4, UGT1A1, and multidrug resistance 1 in a concentration-related manner, with the maximal induction of CYP2B6 challenging that of the induction by rifampicin. Rifampin cytochrome P450 family 2 subfamily B member 6 Homo sapiens