Title : Decarboxylative Grob-type fragmentations in the synthesis of trisubstituted Z olefins: application to peloruside A, discodermolide, and epothilone D.

Pub. Date : 2009

PMID : 19492384






1 Functional Relationships(s)
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1 Discriminating elimination: A new method for the synthesis of methyl-branched trisubstituted Z olefins, a structural motif in many polyketides with anticancer activity, relies on an (-)OH-induced decarboxylative Grob-type fragmentation (see scheme; Ms = mesyl). Polyketides C-X-C motif chemokine ligand 2 Homo sapiens