Title : Concomitant exposure of ovarian cancer cells to docetaxel, CPT-11 or SN-38 and adenovirus-mediated p53 gene therapy.

Pub. Date : 2009 Aug

PMID : 19491654






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In OVCAR-3 cells, p53 gene therapy inhibited the cell growth and sensitized cells to CPT-11/SN-38, but not to docetaxel. Irinotecan tumor protein p53 Homo sapiens
2 In OVCAR-3 cells, p53 gene therapy inhibited the cell growth and sensitized cells to CPT-11/SN-38, but not to docetaxel. Irinotecan tumor protein p53 Homo sapiens
3 These results support the combination of p53 gene therapy with topoisomerase I inhibitors SN-38/CPT-11 when tumour cells contain mutated p53. Irinotecan tumor protein p53 Homo sapiens
4 These results support the combination of p53 gene therapy with topoisomerase I inhibitors SN-38/CPT-11 when tumour cells contain mutated p53. Irinotecan tumor protein p53 Homo sapiens