Title : Induction of a mutant phenotype in human repair proficient cells after overexpression of a mutated human DNA repair gene.

Pub. Date : 1991 Oct 25

PMID : 1945841






1 Functional Relationships(s)
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1 Whereas antisense RNA did not influence the survival of the transfected cells, a mutated cDNA generating an ERCC-1 protein with two extra amino acids in a conserved region of its C-terminal part resulted in a significant sensitization of the HeLa transfectants to mitomycin C-induced damage. Mitomycin ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens