Title : Arsenic trioxide induces apoptosis and G2/M phase arrest by inducing Cbl to inhibit PI3K/Akt signaling and thereby regulate p53 activation.

Pub. Date : 2009 Nov 1

PMID : 19457607






1 Functional Relationships(s)
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1 The PI3K/Akt inhibitor LY294002 significantly increased the amount of p53 protein and ATO-induced apoptosis in both cell lines and decreased G2/M phase arrest of MGC803 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one tumor protein p53 Homo sapiens