Pub. Date : 2010 Jan
PMID : 19453623
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Adrenocorticotrophic hormone (ACTH) responsiveness to ghrelin increases after 6 months of ketoconazole use in patients with Cushing"s disease: comparison with GH-releasing peptide-6 (GHRP-6). | Ghrelin | proopiomelanocortin | Homo sapiens |
| 2 | BACKGROUND: In Cushing"s disease (CD), adrenocorticotrophic hormone (ACTH)/cortisol responses to growth hormone secretagogues (GHS), such as ghrelin and GHRP-6, are exaggerated. | Ghrelin | proopiomelanocortin | Homo sapiens |
| 3 | OBJECTIVE: To compare ghrelin- and GHRP-6-induced ACTH/cortisol release before and after ketoconazole treatment in patients with CD. | Ghrelin | proopiomelanocortin | Homo sapiens |
| 4 | An increase in basal ACTH (before: 11.2 +/- 1.6 pmol/l; 6th month: 19.4 +/- 2.7) and in ghrelin-stimulated peak ACTH values occurred after 6 months (before: 59.8 +/- 15.4; 6th month: 112.0 +/- 11.2). | Ghrelin | proopiomelanocortin | Homo sapiens |
| 5 | The enhanced ACTH responses to ghrelin after ketoconazole in CD could also be due to activation of the hypothalamic-pituitary-adrenal axis and/or to an increase in GHS-receptors expression in the corticotroph adenoma, consequent to reductions in circulating glucocorticoids. | Ghrelin | proopiomelanocortin | Homo sapiens |