Title : Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) controls activation of extracellular signal-regulated kinase (ERK) signaling in the striatum and long-term behavioral responses to cocaine.

Pub. Date : 2009 Oct 15

PMID : 19446794






2 Functional Relationships(s)
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1 In the striatum, ERK1/2 kinases are co-activated by glutamate and dopamine D1/5 receptors, but the mechanisms providing such signaling integration are still unknown. Glutamic Acid mitogen-activated protein kinase 3 Mus musculus
2 RESULTS: Phosphorylation of ERK1/2 in response to glutamate, dopamine D1 agonist, or both stimuli simultaneously is impaired in Ras-GRF1-deficient striatal cells and organotypic slices of the striatonigral MSN compartment. Glutamic Acid mitogen-activated protein kinase 3 Mus musculus