Pub. Date : 2009 Sep
PMID : 19443572
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of forkhead box O1 protects pancreatic beta-cells against dexamethasone-induced dysfunction. | Dexamethasone | forkhead box O1 | Rattus norvegicus |
| 2 | Forkhead Box O1 (FoxO1) is a key transcription regulator of insulin/IGF-I signaling pathway, and its activity can be increased by dexamethasone (DEX) in several cell types. | Dexamethasone | forkhead box O1 | Rattus norvegicus |
| 3 | Forkhead Box O1 (FoxO1) is a key transcription regulator of insulin/IGF-I signaling pathway, and its activity can be increased by dexamethasone (DEX) in several cell types. | Dexamethasone | forkhead box O1 | Rattus norvegicus |
| 4 | Forkhead Box O1 (FoxO1) is a key transcription regulator of insulin/IGF-I signaling pathway, and its activity can be increased by dexamethasone (DEX) in several cell types. | Dexamethasone | forkhead box O1 | Rattus norvegicus |
| 5 | Forkhead Box O1 (FoxO1) is a key transcription regulator of insulin/IGF-I signaling pathway, and its activity can be increased by dexamethasone (DEX) in several cell types. | Dexamethasone | forkhead box O1 | Rattus norvegicus |
| 6 | However, the role of FoxO1 in DEX-induced pancreatic beta-cell dysfunction has not been fully understood. | Dexamethasone | forkhead box O1 | Rattus norvegicus |
| 7 | Therefore, in this study, we investigated whether FoxO1 could mediate DEX-induced beta-cell dysfunction and the possible underlying mechanisms in pancreatic beta-cell line RINm5F cells and primary rat islet. | Dexamethasone | forkhead box O1 | Rattus norvegicus |
| 8 | We found that DEX markedly increased FoxO1 mRNA and protein expression and decreased FoxO1 phosphorylation through the Akt pathway, which resulted in an increase in active FoxO1 in RINm5F cells and isolated rat islets. | Dexamethasone | forkhead box O1 | Rattus norvegicus |
| 9 | We found that DEX markedly increased FoxO1 mRNA and protein expression and decreased FoxO1 phosphorylation through the Akt pathway, which resulted in an increase in active FoxO1 in RINm5F cells and isolated rat islets. | Dexamethasone | forkhead box O1 | Rattus norvegicus |
| 10 | We found that DEX markedly increased FoxO1 mRNA and protein expression and decreased FoxO1 phosphorylation through the Akt pathway, which resulted in an increase in active FoxO1 in RINm5F cells and isolated rat islets. | Dexamethasone | forkhead box O1 | Rattus norvegicus |
| 11 | Knockdown of FoxO1 by RNA interference restored the expression of pancreatic duodenal homeobox-1 and prevented DEX-induced dysfunction of glucose-stimulated insulin secretion in rat islets. | Dexamethasone | forkhead box O1 | Rattus norvegicus |
| 12 | Together, the results of present study demonstrate that FoxO1 is integrally involved in DEX-induced inhibition of pancreatic duodenal homeobox-1 and glucose-stimulated insulin secretion dysfunction in pancreatic islet beta-cells. | Dexamethasone | forkhead box O1 | Rattus norvegicus |
| 13 | Inhibition of FoxO1 can effectively protect beta-cells against DEX-induced dysfunction. | Dexamethasone | forkhead box O1 | Rattus norvegicus |