Title : The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1.

Pub. Date : 2009 Jun 2

PMID : 19439663






1 Functional Relationships(s)
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1 We show that full-length IL-33(1-270) binds and activates ST2, similarly to IL-33(112-270), and that cleavage by caspase-1 does not occur at the site initially proposed (Ser(111)), but rather after residue Asp(178) between the fourth and fifth predicted beta-strands of the IL-1-like domain. Aspartic Acid caspase 1 Homo sapiens