Pub. Date : 2009 Jul-Aug
PMID : 19438225
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | (-)-Epigallocatechin-3-gallate inhibits Hsp90 function by impairing Hsp90 association with cochaperones in pancreatic cancer cell line Mia Paca-2. | epigallocatechin gallate | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 2 | (-)-Epigallocatechin-3-gallate inhibits Hsp90 function by impairing Hsp90 association with cochaperones in pancreatic cancer cell line Mia Paca-2. | epigallocatechin gallate | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 3 | (-)-EGCG was reported to bind to the C-terminal domain of heat shock protein 90 (Hsp90). | epigallocatechin gallate | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 4 | (-)-EGCG was reported to bind to the C-terminal domain of heat shock protein 90 (Hsp90). | epigallocatechin gallate | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 5 | The purpose of this study is to investigate (-)-EGCG as a novel Hsp90 inhibitor to impair Hsp90 superchaperone complex for simultaneous downregulation of oncogenic proteins in pancreatic cancer cells. | epigallocatechin gallate | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 6 | The purpose of this study is to investigate (-)-EGCG as a novel Hsp90 inhibitor to impair Hsp90 superchaperone complex for simultaneous downregulation of oncogenic proteins in pancreatic cancer cells. | epigallocatechin gallate | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 7 | Western blotting analysis demonstrated that (-)-EGCG induced downregulation of oncogenic Hsp90 client proteins by approximately 70-95%, including Akt, Cdk4, Raf-1, Her-2, and pERK. | epigallocatechin gallate | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 8 | Co-immunoprecipitation showed that (-)-EGCG decreased the association of cochaperones p23 and Hsc70 with Hsp90 by more than 50%, while it had little effect on the ATP binding to Hsp90. | epigallocatechin gallate | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 9 | Proteolytic fingerprinting assay confirmed direct binding between (-)-EGCG and the Hsp90 C-terminal domain. | epigallocatechin gallate | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 10 | These data suggest that the binding of (-)-EGCG to Hsp90 impairs the association of Hsp90 with its cochaperones, thereby inducing degradation of Hsp90 client proteins, resulting antiproliferating effects in pancreatic cancer cells. | epigallocatechin gallate | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 11 | These data suggest that the binding of (-)-EGCG to Hsp90 impairs the association of Hsp90 with its cochaperones, thereby inducing degradation of Hsp90 client proteins, resulting antiproliferating effects in pancreatic cancer cells. | epigallocatechin gallate | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 12 | These data suggest that the binding of (-)-EGCG to Hsp90 impairs the association of Hsp90 with its cochaperones, thereby inducing degradation of Hsp90 client proteins, resulting antiproliferating effects in pancreatic cancer cells. | epigallocatechin gallate | heat shock protein 90 alpha family class A member 1 | Homo sapiens |