Pub. Date : 2009 Jul
PMID : 19429816
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Overexpression of CYP2J2 provides protection against doxorubicin-induced cardiotoxicity. | Doxorubicin | cytochrome P450 family 2 subfamily J member 2 | Homo sapiens |
| 2 | However, cardiac function, assessed by measurement of fractional shortening with M-mode transthoracic echocardiography, was significantly higher in CYP2J2 Tr than WT hearts after chronic Dox treatment (WT 37 +/- 2%, CYP2J2 Tr 47 +/- 1%). | Doxorubicin | cytochrome P450 family 2 subfamily J member 2 | Homo sapiens |
| 3 | Together, these data suggest that cardiac-specific overexpression of CYP2J2 limited Dox-induced toxicity. | Doxorubicin | cytochrome P450 family 2 subfamily J member 2 | Homo sapiens |