Title : 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibits fibrogenic response in human hepatoma cells.

Pub. Date : 2009 May 22

PMID : 19429239






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 15d-PGJ(2) significantly inhibited TGF-beta-induced CTGF protein and mRNA expressions, and promoter activity in hepatoma cells. 15d-pgj cellular communication network factor 2 Homo sapiens
2 The results suggest that 15d-PGJ(2) inhibits TGF-beta-induced CTGF expression by inhibiting the phosphorylation of Smad2, which is independent of PPAR, and 15d-PGJ(2) might also act through a PPAR-dependent mechanism in human hepatoma cells. 15d-pgj cellular communication network factor 2 Homo sapiens