Pub. Date : 2010 Apr
PMID : 19427778
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Docosahexaenoic acid down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes via the sphingomyelinase/ceramide pathway. | Phenobarbital | cytochrome P450 2B1 | Rattus norvegicus |
| 2 | In addition, the cAMP-dependent PKA pathway down-regulates CYP 2B1 expression induced by phenobarbital (PB). | Phenobarbital | cytochrome P450 2B1 | Rattus norvegicus |
| 3 | In addition, the cAMP-dependent PKA pathway down-regulates CYP 2B1 expression induced by phenobarbital (PB). | Phenobarbital | cytochrome P450 2B1 | Rattus norvegicus |
| 4 | In the present study, we determined the effect of DHA on SMase transactivation and the downstream pathway in CYP 2B1 expression induced by PB. | Phenobarbital | cytochrome P450 2B1 | Rattus norvegicus |
| 5 | SMase was activated by DHA 2 h after treatment, and D609 (an SMase inhibitor) attenuated the inhibition of PB-induced CYP 2B1 expression by DHA. | Phenobarbital | cytochrome P450 2B1 | Rattus norvegicus |
| 6 | C2-ceramide dose-dependently inhibited PB-induced CYP 2B1 expression and increased intracellular cAMP concentrations. | Phenobarbital | cytochrome P450 2B1 | Rattus norvegicus |
| 7 | SQ22536 (an adenylyl cyclase inhibitor) and H89 (a PKA-specific inhibitor) partially reversed the inhibition of PB-induced CYP 2B1 expression by C2-ceramide. | Phenobarbital | cytochrome P450 2B1 | Rattus norvegicus |