Title : The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib.

Pub. Date : 2009 May 15

PMID : 19417138






2 Functional Relationships(s)
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1 We show that induction of autophagy by Bortezomib is dependent on the proteasomal stabilisation of ATF4 and up-regulation of LC3B by ATF4. Bortezomib microtubule associated protein 1 light chain 3 beta Homo sapiens
2 We show that ATF4 and LC3B play a critical role in activating autophagy and protecting cells from Bortezomib-induced cell death. Bortezomib microtubule associated protein 1 light chain 3 beta Homo sapiens