Title : Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil.

Pub. Date : 2009 Apr 28

PMID : 19402749






1 Functional Relationships(s)
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1 Using genetic and biochemical tools, we found that inactivation of TDG significantly increases resistance of both mouse and human cancer cells towards 5-FU. Fluorouracil thymine DNA glycosylase Mus musculus