Title : Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease.

Pub. Date : 2010 Feb 9

PMID : 19394403






1 Functional Relationships(s)
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1 Set against a historical background, we review data supporting the idea that metabolites of the kynurenine pathway (KP) of tryptophan degradation provide a critical link between mutant htt and the pathophysiology of HD. Kynurenine huntingtin Homo sapiens