Title : Estrogen attenuates glutamate-induced cell death by inhibiting Ca2+ influx through L-type voltage-gated Ca2+ channels.

Pub. Date : 2009 Jun 18

PMID : 19389388






2 Functional Relationships(s)
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1 Glutamate treatment significantly increased both intracellular free Ca(2+) and the activities of downstream proteases such as calpain and caspase-3. Glutamic Acid caspase 3 Homo sapiens
2 From these observations, we conclude that estrogen limits glutamate-induced cell death in VSC 4.1 cells through effects on L-type Ca(2+) channels, inhibiting Ca(2+) influx as well as activation of the pro-apoptotic proteases calpain and caspase-3. Glutamic Acid caspase 3 Homo sapiens