Pub. Date : 2009 Jul 9
PMID : 19383624
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vitro and in vivo studies have investigated the catabolic effects of Dex at therapeutic doses on skeletal muscle, demonstrating an increase in the expression of GDF8 (myostatin) gene, a well-known negative regulator of skeletal muscle mass, in a dose-dependent way. | Dexamethasone | myostatin | Bos taurus |
| 2 | In vitro and in vivo studies have investigated the catabolic effects of Dex at therapeutic doses on skeletal muscle, demonstrating an increase in the expression of GDF8 (myostatin) gene, a well-known negative regulator of skeletal muscle mass, in a dose-dependent way. | Dexamethasone | myostatin | Bos taurus |
| 3 | This suggested a direct role of myostatin in Dex-induced muscle wasting. | Dexamethasone | myostatin | Bos taurus |
| 4 | Data analysis demonstrates that the expression profiles were strongly affected by Dex treatment with hundreds of genes upregulated with relevant fold-change, whereas seven genes were downregulated including the myostatin gene. | Dexamethasone | myostatin | Bos taurus |