Title : Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension.

Pub. Date : 2009 May 5

PMID : 19380617






2 Functional Relationships(s)
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1 Combined IK1/SK3 deficiency in IK1(-/-)/SK3(T/T) (+doxycycline) mice abolished endothelial K(Ca) currents and impaired acetylcholine-induced smooth muscle hyperpolarization and EDHF-mediated dilation in conduit arteries and in resistance arterioles in vivo. Acetylcholine potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 Mus musculus
2 Combined IK1/SK3 deficiency in IK1(-/-)/SK3(T/T) (+doxycycline) mice abolished endothelial K(Ca) currents and impaired acetylcholine-induced smooth muscle hyperpolarization and EDHF-mediated dilation in conduit arteries and in resistance arterioles in vivo. Acetylcholine potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 Mus musculus