Title : Exposure to polybrominated diphenyl ethers 203 and 206 during the neonatal brain growth spurt affects proteins important for normal neurodevelopment in mice.

Pub. Date : 2009 Jun

PMID : 19380496






2 Functional Relationships(s)
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1 The protein analysis showed that CaMKII and synaptophysin increased significantly in the hippocampus, but not in the cerebral cortex, after neonatal exposure to PBDE 203 or 206. Halogenated Diphenyl Ethers synaptophysin Mus musculus
2 In addition, the increases in CaMKII and synaptophysin are the same changes seen after neonatal PBDE 209 exposure; supporting the suggestion that PBDE 209 must be metabolized, likely debrominated into lower brominated PBDEs, to exert its neurotoxic effects. Halogenated Diphenyl Ethers synaptophysin Mus musculus