Title : ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells.

Pub. Date : 2009 Apr

PMID : 19372587






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Both Src and STAT3 inhibitors restored Taxol sensitivity in resistant ErbB2-overexpressing breast cancer cells. Paclitaxel signal transducer and activator of transcription 3 Homo sapiens
2 Our data suggest that ErbB2 overexpression can activate STAT3 through Src leading to transcriptional up-regulation of p21(Cip1) that confers Taxol resistance of breast cancer cells. Paclitaxel signal transducer and activator of transcription 3 Homo sapiens
3 Our study suggests a potential clinical application of Src and STAT3 inhibitors in Taxol sensitization of ErbB2-overexpressing breast cancers. Paclitaxel signal transducer and activator of transcription 3 Homo sapiens