Title : In vitro metabolism of the novel, highly selective oral angiogenesis inhibitor motesanib diphosphate in preclinical species and in humans.

Pub. Date : 2009 Jul

PMID : 19372226






1 Functional Relationships(s)
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1 Incubations with recombinant human UDP-glucuronosyltransferases (UGTs) and inhibition by the UGT1A4 and UGT1A1 substrates/inhibitors imipramine and bilirubin suggested that UGT1A4 is the major UGT isozyme catalyzing the N-glucuronidation of motesanib, with a minor contribution from UGT1A1. Nitrogen UDP glucuronosyltransferase family 1 member A1 Homo sapiens