Title : Identification of a key residue determining substrate affinity in the human glucose transporter GLUT1.

Pub. Date : 2009 May

PMID : 19366592






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 The functional role of Ile(287) in human GLUT1, which corresponds to Asn(331) in Hxt2, was studied by its replacement with each of the other 19 amino acids. Isoleucine solute carrier family 2 member 1 Homo sapiens
2 These results suggest that Ile(287) is a key residue for maintaining high glucose affinity in GLUT1 as revealed in Hxt2 and is located at or near the exofacial glucose binding site. Isoleucine solute carrier family 2 member 1 Homo sapiens