Title : ARF6-mediated endosome recycling reverses lipid accumulation defects in Niemann-Pick Type C disease.

Pub. Date : 2009

PMID : 19365558






3 Functional Relationships(s)
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1 Here we report that nucleotide cycling or cellular knockdown of the small GTP-binding protein, ARF6, markedly impacts cholesterol homeostasis. Guanosine Triphosphate ADP ribosylation factor 6 Homo sapiens
2 We also show that fibroblasts derived from different NPC patients displayed varying levels of ARF6 that is GTP-bound, which correlate with their response to sustained ARF6 activation. Guanosine Triphosphate ADP ribosylation factor 6 Homo sapiens
3 We also show that fibroblasts derived from different NPC patients displayed varying levels of ARF6 that is GTP-bound, which correlate with their response to sustained ARF6 activation. Guanosine Triphosphate ADP ribosylation factor 6 Homo sapiens