Title : Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells.

Pub. Date : 2009 Jun

PMID : 19364129






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Overexpression of 14-3-3zeta in MM cells attenuated ATO-induced cell death, whereas RNAi-based 14-3-3zeta knock-down or the inhibition of HSP90 enhanced tumor cell sensitivity to the ATO induction. Arsenic Trioxide tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta Homo sapiens
2 Overexpression of 14-3-3zeta in MM cells attenuated ATO-induced cell death, whereas RNAi-based 14-3-3zeta knock-down or the inhibition of HSP90 enhanced tumor cell sensitivity to the ATO induction. Arsenic Trioxide tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta Homo sapiens
3 These observations implicate 14-3-3zeta and HSP90 as potential molecular targets for drug intervention of multiple myeloma and thus improve our understanding on the mechanisms of antitumor activity of ATO. Arsenic Trioxide tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta Homo sapiens