Title : Feed-forward signaling of TNF-alpha and NF-kappaB via IKK-beta pathway contributes to insulin resistance and coronary arteriolar dysfunction in type 2 diabetic mice.

Pub. Date : 2009 Jun

PMID : 19363130






1 Functional Relationships(s)
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1 The protein expression of IKK-alpha and IKK-beta were higher in Lepr(db) than in mLepr(db) mice; the expression of IKK-beta, but not the expression of IKK-alpha, was attenuated by MG-132, the antioxidant apocynin, or the genetic deletion of TNF-alpha in diabetic mice. benzyloxycarbonylleucyl-leucyl-leucine aldehyde conserved helix-loop-helix ubiquitous kinase Mus musculus