Title : The C-terminal active site cysteine of Escherichia coli glutaredoxin 1 determines the glutathione specificity of the second step of peptide deglutathionylation.

Pub. Date : 2009 Aug

PMID : 19361272






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Mutating Tyr13, Thr58, and/or Asp74 to alanine in E. coli Grx1 results in the glutaredoxin-peptide mixed disulfide being thermodynamically favored over the glutaredoxin-glutathione mixed disulfide in the first step of the reaction. Disulfides dithiol glutaredoxin GRX1 Saccharomyces cerevisiae S288C
2 Mutating Tyr13, Thr58, and/or Asp74 to alanine in E. coli Grx1 results in the glutaredoxin-peptide mixed disulfide being thermodynamically favored over the glutaredoxin-glutathione mixed disulfide in the first step of the reaction. Disulfides dithiol glutaredoxin GRX1 Saccharomyces cerevisiae S288C