Title : Inhibition of ataxia telangiectasia mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells.

Pub. Date : 2009 Apr 15

PMID : 19351839






1 Functional Relationships(s)
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1 Pretreatment of several melanoma lines just before gamma-irradiation with the inhibitor of ATM kinase KU-55933 suppressed p53 and nuclear factor-kappaB (NF-kappaB) activation but notably increased radiation-induced DR5 surface expression, down-regulated cFLIP (caspase-8 inhibitor) levels, and substantially enhanced exogenous TRAIL-induced apoptosis. 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one tumor protein p53 Homo sapiens