Pub. Date : 2009 Mar 20
PMID : 19348736
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibitory effects of Group I metabotropic glutamate receptors antagonists on the expression of NMDA receptor NR1 subunit in morphine tolerant rats. | Morphine | glutamate ionotropic receptor NMDA type subunit 1 | Rattus norvegicus |
| 2 | The expression of NR1 was upregulated in the dorsal horn of spinal cord after chronic morphine treatment. | Morphine | glutamate ionotropic receptor NMDA type subunit 1 | Rattus norvegicus |
| 3 | AIDA or MPEP co-administered with morphine attenuated morphine induced upregulation of NR1. | Morphine | glutamate ionotropic receptor NMDA type subunit 1 | Rattus norvegicus |
| 4 | AIDA or MPEP co-administered with morphine attenuated morphine induced upregulation of NR1. | Morphine | glutamate ionotropic receptor NMDA type subunit 1 | Rattus norvegicus |
| 5 | These findings suggest that the development of morphine tolerance partly prevented by Group I mGluRs antagonists may due to its inhibitory effect on the expression of NR1 subunit. | Morphine | glutamate ionotropic receptor NMDA type subunit 1 | Rattus norvegicus |