Title : Multifunctional role of His159in the catalytic reaction of serine palmitoyltransferase.

Pub. Date : 2009 Jun 5

PMID : 19346561






3 Functional Relationships(s)
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1 Global analysis of the time-resolved spectra suggested the presence of the two quinonoid intermediates, the first formed from the PLP-l-serine aldimine and the second from the PLP-KDS aldimine. quinonoid pyridoxal phosphatase Homo sapiens
2 Accumulation of these quinonoid intermediates indicated that His(159) promotes both the Claisen-type condensation as an acid catalyst and the protonation at Calpha of the second quinonoid to form the PLP-KDS aldimine. quinonoid pyridoxal phosphatase Homo sapiens
3 Accumulation of these quinonoid intermediates indicated that His(159) promotes both the Claisen-type condensation as an acid catalyst and the protonation at Calpha of the second quinonoid to form the PLP-KDS aldimine. quinonoid pyridoxal phosphatase Homo sapiens